Breakthrough in nanoscale force measurement

Super-resolved photonic force microscopy for detecting ultra-weak interaction forces between nanoparticles and surfaces
Credit: Lei Ding

…opens doors to unprecedented biological insights.

Groundbreaking research has revealed a new way to measure incredibly minute forces at the nanoscale in watery solutions, pushing the boundaries of what scientists know about the microscopic world.

The significant nanotechnology advance was achieved by researchers from Beihang University in China with RMIT University and other leading institutions including the Australian National University and University of Technology Sydney.

The new technique, involving a super-resolved photonic force microscope (SRPFM), is capable of detecting forces in water as small as 108.2 attonewtons—a scale so minute that it compares to measuring the weight of a virus.

Lead researcher from Beihang University, Professor Fan Wang, said the key to this ultra-sensitive measurement lay in the use of lanthanide-doped nanoparticles, trapped by optical tweezers, which are then used to probe the minute forces at play within biological systems.

“Understanding these tiny forces is crucial for the study of biomechanical processes, which are fundamental to the workings of living cells,” he said.

“Until now, measuring such small forces with high precision in a liquid environment was a significant challenge due to factors like probe heating and weak signal issues.”

The SRPFM technique developed by Wang and his team addresses these challenges by employing advanced nanotechnology and computational techniques.

By leveraging neural network-empowered super-resolution localisation, the team is able to precisely measure how the nanoparticles are displaced by tiny forces within a fluid medium.

Study co-first author from RMIT University, Dr Lei Ding, said this innovation not only enhances the resolution and sensitivity of force measurements but also minimizes the energy required to trap the nanoparticles, thereby reducing potential damage to biological samples.

“Our method can detect forces down to 1.8 femtonewtons per square root of the bandwidth, which is near the theoretical limit imposed by thermal noise,” Ding said.

The implications of this research are vast, added Dr Xuchen Shan, co-first author from Beihang University

“By providing a new tool to measure biological events at the molecular level, this technique could revolutionize our understanding of a host of biological and physical phenomena,” Shan said.

This includes everything from how proteins function within human cells to new methods of detecting diseases at an early stage.

The study also explored the application of this technology in measuring electrophoresis forces acting on single nanoparticles and the interaction forces between DNA molecule and interfaces, crucial for the development of advanced biomedical engineering techniques.

The team’s findings not only pave the way for new scientific discoveries but also have potential applications in the development of new nanotechnological tools and improving the sensitivity of biomedical diagnostics.

‘Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy’ Shan, X., Ding, L., Wang, D. et al. was published in Nature Photonics  (DOI: 10.1038/s41566-024-01462-7)

Journal: Nature Photonics
DOI: 10.1038/s41566-024-01462-7
Method of Research: Observational study
Subject of Research: Cells
Article Title: Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy
Article Publication Date: 14-Jun-2024

Media Contact

Michael Quin
RMIT University
Cell: 61-499 515 417

Media Contact

Michael Quin
RMIT University

All latest news from the category: Medical Engineering

The development of medical equipment, products and technical procedures is characterized by high research and development costs in a variety of fields related to the study of human medicine.

innovations-report provides informative and stimulating reports and articles on topics ranging from imaging processes, cell and tissue techniques, optical techniques, implants, orthopedic aids, clinical and medical office equipment, dialysis systems and x-ray/radiation monitoring devices to endoscopy, ultrasound, surgical techniques, and dental materials.

Back to home

Comments (0)

Write a comment

Newest articles

World’s first method

Successful surgery for a rare congenital heart disease “scimitar syndrome”. Scimitar syndrome, a rare congenital heart disease, involves an anomalous pulmonary venous return where the right pulmonary veins return to…

Improving HIV treatment in children and adolescents – the right way!

Globally, around 2.6 million children and adolescents are currently living with HIV, the majority of them in Africa. These young people are much more likely to experience treatment failure than…

Study shows promise for a universal influenza vaccine

OHSU-led research uses innovative vaccine platform to target interior of virus; scientists validate theory using 1918 flu virus. New research led by Oregon Health & Science University reveals a promising…

Partners & Sponsors