Cells that did not find place in life

The cell being in permanent futile search – is a cancer cell. This hypothesis was set forward by Russian scientists Yuri Vasiliev and I.M. Gelfand in the review article published in the Biochemistry journal (2006, Volume 71, No. 8).

For an organism to originate from cells, it is necessary that cells could find each other. To this end, they undertake searching migrations. As a rule, searching migration has two stages. At the search stage, a group of cells or even not cells per se but their processes move in a random way along acellular spaces of the organism, one might say, they fumble about by touch. Some of them grope after something, and then there comes a stage of choice for them. Migrating cells that have achieved definite places in the organism, stop and start differentiation. Embyronic growth is impossible without searching migration. In particular, when the nervous system is being formed, nerve cells of the spinal cord rudiment release processes (axons) into the body cavity, the processes touch the cavity and within some time they hit on some “target”, for example, muscle rudiments. Then synapse – neuromuscular junction – occurs. Axons from other sections of the brain find rudiments of other organs. Vessel growth can also be considered as peculiar searching reactions, where ends of ramifying capillaries are at first looked for, and then the territory is selected for blood supply. Wound healing begins with searching migration. The choice is as follows: a cell may find its place and make part of an organ or a tissue, or it may not. Unsuccessful search is a commonplace. Thus, when neuromuscular contacts are being formed, only the minority of axons manage to grope the “target”. All other axons and the cells they belong to turn out to be redundant and are subject to extermination – apoptosis.

Malignancy of cancer cells, that is their ability to leave the normal tissue and to spread across the body, is akin to searching migration. However, such migration is considered by the researchers as a pathologic one. Pathologic migration differs radically from the normal one by the fact that it possesses only the first part – wandering- but the choice is absent. Apparently, this pathology occurred as a result of genetic abnormalities in the normal search mechanisms. Malignant cells are constantly wandering in the surrounding tissue, but they do not stop and do not start differentiation. Within the tumors per se, cell displacements are spontaneous and confused. At face value, the cells that did not find their place are subject to destruction, but cancer cells are deprived of the ability for apoptosis, therefore, they survive and reproduce. If the carcinogenesis process has already gone far, cancer cells can leave their native tumor, “wander” rather far from it and form metastases. At earlier stages of carcinogenesis, the cells still preserve some ability for choice, but they pass on to it under the influence of some other factors. Even in the non-malignant tumors, some part of cells is always in the state of search: it reproduces and migrates.

The researchers emphasize that a cancer cell can be called an eternal finder only as a very rough approximation, and all details of the hypothesis suggested by them require experimental validation.

Media Contact

Nadezda Markina alfa

Weitere Informationen:

http://www.informnauka.ru

Alle Nachrichten aus der Kategorie: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

An artificial cell on a chip

Researchers at the University of Basel have developed a precisely controllable system for mimicking biochemical reaction cascades in cells. Using microfluidic technology, they produce miniature polymeric reaction containers equipped with…

Specific and rapid expansion of blood vessels

Nature Communications: KIT researchers identify a new mechanism to control endothelial cell size and arterial caliber – basis for better treatment of heart infarct and stroke. Upon a heart infarct…

Climate change drives plants to extinction in the Black Forest in Germany

Climate change is leaving its mark on the bog complexes of the German Black Forest. Due to rising temperatures and longer dry periods, two plant species have already gone extinct…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close