Discovery of key inflammation mechanism in COPD could lead to new treatments
An international team of researchers has identified a mechanism which increases lung inflammation, making Chronic Obstructive Pulmonary Disorder (COPD) more severe, and potentially points towards new treatments.
Reporting today in the New England Journal of Medicine, the team from Imperial College London, Royal Brompton Hospital and the University of British Columbia, Canada found a correlation between the increase in inflammation in the lungs and a loss of activity in an enzyme responsible for switching off inflammatory genes and cells, called histone deacetylase (HDAC).
Professor Peter Barnes, from Imperial College London and the Royal Brompton Hospital, and senior author of the research, said: “COPD is the only common cause of death in the western world that is increasing, affecting almost a million patients in the UK, and four million in the USA, and the identification of this molecular mechanism could be of enormous importance in how we treat COPD in the future.”
The team believe that the loss of HDAC activity may also explain why COPD is not responsive to steroids, as steroids require HDAC in order to switch off the inflammation.
Previous research by Professor Barnes has shown that low doses of theophylline, a substance occurring in tea leaves which helps relax the bronchial tubes, could help restore HDAC activity, and potentially reverse the resistance to steroids.
Professor Barnes adds: “Although this research is at a fundamental level, the discovery that COPD affects HDAC activity, which in turn can be affected by theophylline, could be the first step towards the development of an effective treatment.”
The researchers looked at lung tissue samples from 40 patients with a range of different COPD stages.
All latest news from the category: Life Sciences and Chemistry
Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Genes associated with hearing loss visualised in new study
Researchers from Uppsala University have been able to document and visualise hearing loss-associated genes in the human inner ear, in a unique collaboration study between otosurgeons and geneticists. The findings…