Region of chromosome 1 important in blood pressure regulation
Scientists are closing in on genetic contributors to high blood pressure and other causes of heart and cardiovascular disease. At the American Society for Human Genetics annual meeting in Los Angeles, Hopkins research associate Yen-Pei Christy Chang, Ph.D., will present evidence that a region of chromosome 1 is involved in appropriately regulating blood pressure. Her talk is scheduled for 10:15 a.m., Saturday, Nov. 8.
The scientists conducted a genome-wide analysis of 1,875 people in 585 families collected through the GenNet network of the National Heart, Lung and Blood Institutes Family Blood Pressure Program. Through their analysis, the scientists linked a region containing more than 200 known genes to blood pressure. The researchers also highlighted 24 genes whose functions might predict some role in hypertension, and closely examined nine of these genes. Their work uncovered genetic changes called single nucleotide polymorphisms (SNPs) in three of these nine that were associated with hypertension.
This region of chromosome 1 has been linked to related disorders such as type 2 diabetes and to a condition called familial hyperlipidemia (in which levels of cholesterol are high). However, this is the first analysis to identify candidate genes for additional study and to offer good evidence that more than one gene in the region is involved in blood pressure regulation, says the studys principal investigator, Aravinda Chakravarti, Ph.D., director of the McKusick-Nathans Institute of Genetic Medicine.
The researchers are continuing to evaluate how the three genes functions might be affected by the observed SNPs, says Chakravarti.
All news from this category: Life Sciences
Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Bringing atoms to a standstill: NIST miniaturizes laser cooling
It’s cool to be small. Scientists at the National Institute of Standards and Technology (NIST) have miniaturized the optical components required to cool atoms down to a few thousandths of…
Record-breaking laser link could help us test whether Einstein was right
Scientists from the International Centre for Radio Astronomy Research (ICRAR) and The University of Western Australia (UWA) have set a world record for the most stable transmission of a laser signal through…
Adaptive optics with cascading corrective elements
A cascaded dual deformable phase plate wavefront modulator enables direct AO integration with existing microscopes–doubling the aberration correction range and greatly improving image quality. Microscopy is the workhorse of contemporary…