Disturbed regulation of insulin production: genome study casts new light on the origin of type 2 diabetes
In Germany, about 8 million people are affected. These numbers could even be an underestimation as a relatively high number of undiagnosed diabetics remains. The newly-published meta analysis 1) on the genetics of type 2 diabetes casts new light on the origin of this disease.
With participation of scientists of the Helmholtz Zentrum Muenchen, the international study confirms findings that the disease is at least partly based on a misregulation of insulin producing cells.
The newly published meta analysis, in which 90 scientists from more than 40 centers were involved, evaluated data of 15 European and American studies. It was possible to identify six new genes that play a role in the development of type 2 diabetes. This brings the number of genes associated with the disease to 16.
Type 2 diabetes is characterized by perpetually raised blood sugar levels, which, untreated, can lead to damage of blood vessels, the kidneys and other important organs. Life style factors, such as overweight and lack of exercise, play an important role for disease aetiology. Nevertheless, a strong genetic component also underlies type 2 diabetes, which has been studied for some years, with the help of linkage and association studies.
The knowledge now gained allows new insights into the mechanisms responsible for the control of blood sugar levels in the blood.
The meta analysis comprises altogether studies with more than 70,000 participants. As a German contribution, data from about 2,700 participants of the KORA study were included. The involved scientists from Germany were Harald Grallert, Dr. Christa Meisinger and Dr. Thomas Illig, from the Helmholtz Zentrum Muenchen, in close collaboration with Dr. Christian Herder and Dr. Wolfgang Rathmann, from the German Diabetes Center in Duesseldorf.
The head of the KORA study (Cooperative Health Research in the Region of Augsburg) is the director of the Institute of Epidemiology in the Helmholtz Zentrum Muenchen, Prof. Dr. Dr. H.-Erich Wichmann. The coordinator of the analysis was Dr. Eleftheria Zeggini, University of Oxford, under the direction of Prof. Mark McCarthy.
Alle Nachrichten aus der Kategorie: Life Sciences
Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Grow faster, die sooner: How growth rates influence the fitness of bacteria
“The fitness of bacteria is more complex than expected,” explains Ulrich Gerland, professor for the theory of complex biosystems at the Technical University of…
Spintronics: Researchers show how to make non-magnetic materials magnetic
In solid-state physics, oxide layers only a few nanometres thick are known to form a so-called two-dimensional electron gas. These thin layers, separated from…
Caterpillars of the wax moth love eating plastic: Fraunhofer LBF investigates degradation process
Within the Framework of a research project on the chemical imaging analysis of plastic digestion in caterpillars (RauPE), a team from Fraunhofer LBF used…