Proteins, like people, act differently when crowded together
Scientists are pursuing a remarkable parallel that exists among the proteins involved in health and disease inside living cells. The cover story in the current issue of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine, focuses on how the study of proteins crowded together inside cells is opening new doors to the prevention, diagnosis, and treatment of disease.
C&EN Senior Editor Celia Henry Arnaud notes that much of the scientific knowledge about proteins comes from research done in watered-down solutions, as if they had much of an airplane or cell to themselves. But cells are packed with proteins, which fill about 30 percent of a cell's volume. In order to understand proteins' actual role, scientists must study proteins under these jam-packed conditions.
The article describes how scientists are forging ahead with research that mimics the real-world conditions under which proteins function in cells. One discovery, for example, indicates that under crowded conditions, a protein involved in Lyme disease changes shape in a way that reveals a potential new target for diagnosing and treating the disease.
ARTICLE FOR IMMEDIATE RELEASE “Close Quarters”
This story is available at http://pubs.acs.org/cen/coverstory/88/8848cover.html
All latest news from the category: Life Sciences and Chemistry
Articles and reports from the Life Sciences and chemistry area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Exploring quantum electron highways with laser light
Spiraling laser light reveals how topological insulators lose their ability to conduct electric current on their surfaces. Topological insulators, or TIs, have two faces: Electrons flow freely along their surface…
First image of antigen-bound T-cell receptor at atomic resolution
Immune system: Antigen binding does not trigger any structural changes in T-cell receptors – Signal transduction probably occurs after receptor enrichment. The immune system of vertebrates is a powerful weapon…