Life Sciences and Chemistry

Inactivating a protein that helps regulate the proliferation of vascular cells increases the chance of developing atherosclerosis, a major cause of heart disease, researchers at UT Southwestern Medical Center at Dallas have discovered.

Vascular vessels endure constant pounding and considerable stresses associated with blood flow. Vascular smooth muscle cells play an important role in the development of blood vessels, providing structural integrity and the ability to dilate and constrict. The

Stanford University Medical Center researchers have identified a protein responsible for ensuring correct skull growth in newborn mice. The protein, called Noggin, inhibits fusion of bony plates in the skull until developmentally appropriate. The scientists hope that Noggin may one day replace surgery as a way to treat premature skull fusion in infants.

“About 1 in 2,000 children has growth plates in their skull that fuse prematurely,” said Michael Longaker, MD. “The brain is rapidly expand

Scientists from the Howard Hughes Medical Institute and their colleagues have unraveled some of the fundamental mysteries about the genetic mechanisms that endow the immune system with its life-saving ability to generate specialized antibodies.

Without genetic fine-tuning, antibodies would be relatively ineffective in finding a good match on the surface of viruses, parasites, and other potentially dangerous foreign pathogens. The findings also reveal the workings of a gene mutation process

The sex of newborns is dictated by the X and Y chromosomes – girls are XX whereas boys are XY. However, new research from Northwestern University has shown that normal testis formation depends on two genes — the so-called male-determining SRY gene, found on the Y chromosome 10 years ago, and a gene called Dax1 on the X (female) chromosome.
Based on the findings of the Northwestern study, published in the May online Nature Genetics, it now appears that Dax1 is required at several points in embr

Building on their 2001 discovery of a cellular doorway used by anthrax toxin to enter cells, University of Wisconsin Medical School researchers have found a second anthrax toxin doorway, or receptor. The finding could offer new clues to preventing the toxin’s entrance into cells.

The researchers also have found that when they isolated a specific segment of the receptor in the laboratory, they could use it as a decoy to lure anthrax toxin away from the real cell receptors, preventing much o

Since Charles Darwin heralded evolution more than 150 years ago, scientists have sought to better understand when and how the vast variety of plants today diverged from common ancestors.

A new University of Georgia study, just published in Nature, demonstrates key events in plant evolution. It allows scientists to infer what the gene order may have looked like in a common ancestor of higher plants. And it shows one way plants may have differentiated from their ancestors and each other.