ATTO-TEC® has developed the second generation of fluorescent dyes which are stable at room temperature for more than six months.
With Atto 520, Atto 565 and Atto 590 we are pleased to offer three stable fluorescent dyes as amine-reactive succinimidyl esters which will be available from November 2001 on. This allows researchers an easy handling for selectively target- labeling by linking a fluorophore to primary amine groups on proteins or modified nucleic acids.
Further stable activate
Chemists build molecules by paring them down
Complex molecules, such as many drugs, can be fiddly to assemble. By binding their starting compounds in chains 1 , chemists in Denmark may have found a way speed the automated chemical synthesis of such complicated products.
Les Miranda and Morten Meldal of Carlsberg University in Copenhagen have solved the following problem. Complex molecules are usually built up from a core with several near-identical hooks on w
Chameleons can reel in prey anywhere within two-and-a-half body lengths of their jaws. Their tongues can overcome even a bird’s weight and reluctance to be eaten. How? Muscles that are unique among backboned animals, researchers now reveal.
Anthony Herrel of the University of Antwerp, Belgium, and colleagues put crickets at different distances from the noses of two chameleon species, Chameleo calyptratus and Chameleo oustaletti. The tongues of these 12-cm-long reptiles pull at maximum stren
Chemists copy bacterial tricks for making clean fuel.
Bacteria are teaching chemists their tips for creating lean, green fuel. US researchers have developed a catalyst based on a bacterial enzyme that converts cheap acids to hydrogen, the ultimate clean power source.
Unlike other fuels, hydrogen is non-polluting: its combustion makes only water, instead of greenhouse gas carbon dioxide or the poison carbon monoxide. Thomas Rauchfuss and colleagues at the University of Illino
Sequencers expose secret chromosome centre.
Februarys celebrations hid a dark secret: the human genome sequencers hadnt touched the hearts of our chromosomes. Now, at last, one chromosomes inscrutable midpoint, its centromere, has given up its genetic secrets.
Centromeres look like the waist in an X. They share out chromosomes fairly when a cell divides. Defective centromeres may underlie many cancers, in which problems with chromosome movement
Stripes help chemists shop for molecules.
Scientists may soon be sticking bar-coded metal rods into molecules to see what they do in a crowd 1 . The rods could help to track the functions and interactions of genes, and may aid drug discovery.
At only a few thousandths of a millimetre long, the rods are small enough to fit inside a single red blood cell. Christine Keating, of Pennsylvania State University, and colleagues cast them inside cylindrical pores in a