New approach in the fight against viruses

Multi-Electrode Layout for Parallel Analysis of Multiple Cell Samples in Microfluic-Chips. Fraunhofer EMFT, Bernd Müller

Most people see vaccinations as a benefit of modern medicine, as they protect against dangerous viral diseases. However, before a vaccine can enter the doctor‘s surgery, it is first tested for its effectiveness in order to ensure reliable protection.

These tests are typically carried out in the laboratory on cultured cells. First the blood serum of a previously vaccinated person is injected into the cell culture, then the test cells are exposed to a virus infection. If the vaccination was successful, the serum contains sufficient neutralizing antibodies against the viruses and the virus contact has no consequences.

This serves as a proof of the efficacy of a vaccine. If the vaccination was not efficient enough, the antibody titres in the serum are not sufficient to completely intercept the viral load. The cells used for the test are then defenceless against the viruses and are infected.

To date, a possible infection of the test cells is analyzed using labour-intensive and expensive staining methods which has an increasingly limiting effect in view of the enormous number of tests required for vaccine development.

Scientists of the Fraunhofer Institute for Biomedical Engineering IBMT in Sulzbach/Saar and the Fraunhofer Facility for Microsystems and Solid State Technologies EMFT on the campus of the University of Regensburg are currently working together with the companies nanoAnalytics GmbH (Münster) and innoMe GmbH (Espelkamp) on a novel solution for the measurement of antiviral neutralizing antibodies.

For this purpose, the test cells are placed on multi-electrode arrays, which allow their infection status to be recorded completely automatically with the aid of electrochemical measuring methods. This replaces the costly staining reactions of conventional tests, which saves time and money.

Another advantage of the new method is that the cells are continuously monitored over a longer period of time. With the previously used staining methods, they are only analyzed at a specific point in time. This provides the researchers with additional information on the time course of the cell reaction that was previously not available.

The consortium has set itself the goal of researching a complete system, including the measuring device, the associated analysis software and the electrode arrays required for cell observation, and implementing it in laboratory set-ups that will pave the way for a later market launch.

The „ViroSens“ project is funded by the Federal Ministry of Education and Research (BMBF) under the KMUinnovativ funding guideline with a total amount of around €2 Million.

Prof. Hagen von Briesen l Fraunhofer IBMT l Phone +49 6897 9071-286 Hagen.Briesen@ibmt.fraunhofer.de

Prof. Joachim Wegener l Fraunhofer EMFT l Phone +49 9471 943 45 46 Joachim.Wegener@emft.fraunhofer.de

https://www.ibmt.fraunhofer.de/en/ibmt-press-releases-2019/press-ViroSens-2019-0…

Media Contact

Dipl.-Phys. Annette Maurer-von der Gathen Fraunhofer-Institut für Biomedizinische Technik IBMT

Alle Nachrichten aus der Kategorie: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

How Stable is the Antarctic Ice Sheet?

Scientists from Heidelberg University investigate which factors determine the stability of ice masses in East Antarctica. As temperatures rise due to climate change, the melting of polar ice sheets is…

Smart sensors for future fast charging batteries

European project “Spartacus” launched Faster charging, longer stability of performance not only for electric vehicles but also for smartphones and other battery powered products. What still sounds like science fiction…

Small molecules control bacterial resistance to antibiotics

Antibiotics have revolutionized medicine by providing effective treatments for infectious diseases such as cholera. But the pathogens that cause disease are increasingly developing resistance to the antibiotics that are most…

Partners

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close