Finnish discovery brings new insight on the functioning of the eye and retinal diseases

Cells of the retinal pigment epithelium. An epithelial cell is in the middle with microvilli (golden), voltage-gated sodium channels (white), and the photoreceptor cells of the retina (blue) made fluorescent and imaged with a high-resolution confocal microscope. The size of the image is 38 x 38 micrometres (one micrometre is one thousandth of a millimetre). Credit: Julia Johansson and Teemu Ihalainen, Tampere University Usage Restrictions: For media use with this press release only

“The research project focused on the retinal pigment epithelium (RPE), a tissue that is critically important to the functioning of the retina. The project revealed proteins in the RPE whose function is essential for neural tissue, but whose prevalence or activity in epithelial tissue has not been previously reported,” says Academy of Finland Research Fellow Soile Nymark from Tampere University.

“These proteins, voltage-gated sodium channels, are typically responsible for generating electrical signals in the nerve cells,” says Nymark.

“Therefore it is exciting to think of what they could do in the epithelial tissue, which is traditionally considered electrically inactive,” Nymark continues.

In order for our vision to work properly, retinal sensory cells need to be constantly renewed, and this renewal requires the operation of a strictly controlled and multistep phagocytosis process in the RPE.

In this process, part of the retinal sensory cell is detached and enclosed within the adjacent epithelium. The epithelial tissue then metabolises these detached parts of the sensory cells in a controlled manner and thus maintains normal functioning of the retina.

The present discovery reveals how the ion channel proteins responsible for the electrical signalling of neurons influence the phagocytosis process. This process is impaired in many retinal degenerative diseases, the most important example being age-related macular degeneration (AMD). The mechanisms and causes of these diseases can now be studied in the light of the new findings, which creates opportunities for the development of curative treatments.

Our present understanding on the functioning of epithelial tissues is strongly based on cell biological studies. In this study at Tampere University, the researchers investigated the epithelial tissue of the eye by utilizing techniques that have traditionally been used to determine the electrical communication of nerve cells.

“This perspective enabled our new observation and highlights that the major role of electrical phenomena and the underlying ion channels in the functioning of epithelial tissue may not yet be fully understood,” Nymark points out.

In the future, the multidisciplinary project will focus in particular on the role of the newly discovered ion channels in the communication between epithelial cells.

###

The research results were reported in the prestigious British BMC Biology journal.

Julia K Johansson; Viivi I Karema-Jokinen; Satu Hakanen; Antti Jylhä; Hannu Uusitalo; Maija Vihinen-Ranta; Heli Skottman; Teemu O Ihalainen; Soile Nymark. Sodium channels enable fast electrical signaling and regulate phagocytosis in the retinal pigment epithelium. BMC Biology BMCB-D-19-00269

Media Contact

Docent Soile Nymark
soile.nymark@tuni.fi
358-408-490-009

 @UniTampere

http://www.uta.fi/ 

Alle Nachrichten aus der Kategorie: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

How Stable is the Antarctic Ice Sheet?

Scientists from Heidelberg University investigate which factors determine the stability of ice masses in East Antarctica. As temperatures rise due to climate change, the melting of polar ice sheets is…

Smart sensors for future fast charging batteries

European project “Spartacus” launched Faster charging, longer stability of performance not only for electric vehicles but also for smartphones and other battery powered products. What still sounds like science fiction…

Small molecules control bacterial resistance to antibiotics

Antibiotics have revolutionized medicine by providing effective treatments for infectious diseases such as cholera. But the pathogens that cause disease are increasingly developing resistance to the antibiotics that are most…

Partners

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close