Fight diabetes with exercise

Positive effects of exercise in diabetes prevention are determined by the patient’s gut microbiome. Hanno Schoeler, Leibniz-HKI

Major causes for type 2 diabetes are an unbalanced diet and lack of exercise. GPs advice patients diagnosed with prediabetes, where the blood sugar level is permanently raised but does not exceed the critical threshold for diabetes, to follow a light exercise regime to prevent the development of type 2 diabetes.

Often this behaviour change is successful; however, there is a small but relevant number of patients, which do not react positively to it. In some rare cases exercise has even a negative effect and causes advancement to type 2 diabetes.

Gianni Panagiotou of the Leibniz Institute for Natural Product Research and Infection Biology, Jena, and colleagues from the University of Hong Kong compared the gut microbiome of prediabetes patients responding to exercise with that of patients unresponsive to it.

39 male individuals diagnosed with prediabetes took part in the study. The analysis revealed a correlation between blood sugar levels, the gut microbiome and exercise. “People with high blood sugar levels react differently to exercise. We were able to show that this variability is caused not only by the composition of the gut microbiome but as well by its functionality.”

The gut microbiome plays an essential role in human metabolism. In responding patients the synthesis capacity of beneficial short chained fatty acids and the catabolism of branched-chain amino acids were enhanced, whereas high levels of harmful metabolic compounds were detected in non-responding test persons.

To verify the findings the gut microbiome of the probands was transferred to obese mice. Only mice treated with microbiota of patients responsive to light exercise showed the same positive effect on their gut microbiome and their metabolism.

In future, the analysis of the gut microbiome can be used to predict therapy response of individual prediabetes patients. “These findings will enable diabetes researchers to develop new stratified therapies”, so Panagiotou.

The microbiome is the entirety of all microbes living in the same environment for example the gut. It is believed that the gut microbiome plays a crucial role in human health and wellbeing. The formation of microbial communities and the interaction within are the focus of the Cluster of Excellence “The Balance of the Microverse” based in Jena.

Gianni Panagiotou is member of this cluster and of the Collaborative Research Centre FungiNet. He is as well coordinator of the Marie Skłodowska-Curie training network BestTreat. The study is aligned to research performed by his group in the course of these activities. The study was published in Cell Metabolism, and is chosen as research highlight in the next issues of Nature and Nature Endocrinology.

Assoc. Prof. Gianni Panagiotou

Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, Xia Z, Ye D, Guo J, Tse MA, Panagiotou G, Xu A (2019) Gut microbiome fermentation determines the efficacy of exercise for diabetes prevention. Cell Metabolism, https://doi.org/10.1016/j.cmet.2019.11.001.

Media Contact

Dr. Michael Ramm idw - Informationsdienst Wissenschaft

Further information:

https://www.leibniz-hki.de

All news from this category: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Back to the Homepage

Comments (0)

Write comment

Latest posts

Acute itching in eczema patients linked to environmental allergens

Newly identified pathway explains why antihistamine drugs often don’t work to control severe itch. In addition to a skin rash, many eczema sufferers also experience chronic itching, but sometimes that…

Simulating evolution to understand a hidden switch

Computer simulations of cells evolving over tens of thousands of generations reveal why some organisms retain a disused switch mechanism that turns on under severe stress, changing some of their…

How cells move and don’t get stuck

Cell velocity, or how fast a cell moves, is known to depend on how sticky the surface is beneath it, but the precise mechanisms of this relationship have remained elusive…

Partners & Sponsors

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close