New Diagnostic Tools and Biomarkers

New biomarkers allow improved diagnosis of patients presenting shortness of breath.

BACH study shows that MR-proANP adds additional information on standard of care in the diagnosis of acute congestive heart failure. The use of PCT (procalcitonin) together with MR-proANP supports the differential diagnosis of pneumonia and congestive heart failure.

Patients presenting shortness of breath on arrival at the emergency department (ED) can gain from improved diagnosis allowing physicians to distinguish congestive heart failure patients from those presenting pneumonia.

The Bach study, a worldwide multi-centre study with over 1600 patients, reveals the equivalence of MR-proANP (mid-regional atrial natriuretic peptide) to BNP and NT-proBNP for the diagnosis of patients with acute congestive heart failure (CHF) presenting to the emergency department (ED) with shortness of breath (SOB). Especially in diagnostically challenging big subgroups of patients with obesity (BMI = 30 kg/m2), higher age (= 70 years), renal dysfunction or BNP values in the so-called grey zone (= 100 and

Adding PCT (procalcitonin) as a marker of bacterial infection in a model with basic clinical variables supports the clinically very important differential diagnosis of pneumonia and congestive heart failure in patients presenting to the emergency department with shortness of breath, which was present in a substantial number of the patients having a primary diagnosis of acute CHF.

The study allowed the BACH investigators to conclude:

1) MR-proANP is equally useful as BNP and NT-BNP in the diagnosis of acute heart failure

2) In patient subgroups where BNP and NT-proBNP values prove difficult to interpret, MR-proANP provides additive value for the diagnosis of acute heart failure

3) A combination of the biomarkers PCT and MR-proANP helps in the discrimination of patients with pneumonia in comparison to those with heart failure

“Previous retrospective data from our markers were already very good, but the recent BACH data exceeded our expectations by far”, said Andreas Bergmann PhD, Head of Research & Development and Member of the Board. “It is our goal to provide highly effective biomarker assays to support physicians in the management of severely ill patients. Therefore, the highly positive BACH data are very important and improve daily clinical practice.”

Additional results of the BACH trial are scheduled for publication during the upcoming AHA (American Heart Association) congress in New Orleans in November 2008.

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Jacqueline Partarrieu alfa

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