Bacteria-infecting viruses bind mucosal surface and protect from disease
The mucosal surfaces are important for protection of tissues and homeostasis, but often targeted by disease-causing bacteria. Phages have been suggested to specifically bind to host mucosal surfaces and prevent colonization by pathogenic bacteria.
In this symbiotic model phage populations are enriched in the mucus, a substrate in which encounters with their bacterial hosts are more probable, while the animal benefits from protection against invading bacteria.
Researchers at the University of Jyväskylä tested this idea using rainbow trout, phages (viruses) and a fish-infecting bacterium (Flavobacterium columnare). Phages were found to bind to fish mucosa, and maintain there for several days.
Phages bound in mucus also protected the fish from diseases, although the pathogenic bacteria had a strong chemotaxis towards mucus, and exposure to mucosal molecules made them more virulent.
However, the mucosal environment made the bacteria more susceptible for phage infections, revealing a new aspect of the tripartite interactions between mucosal surfaces, bacteria and phages.
In conclusion, the mucosal environment influence both bacteria and phages. These interactions are important for understanding disease ecology and has significant impact in preventive phage therapy approaches.
The research has been published in mBio: https:/
For further information:
Postdoctoral researcher Gabriel Almeida, firstname.lastname@example.org
Communications officer, Tanja Heikkinen, email@example.com, tel. 050 581 8351
Facebook: jyuscience Twitter: jyscience Instagram: jyscience
Alle Nachrichten aus der Kategorie: Life Sciences
Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.
Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.
Nanomaterials enable dual-mode heating and cooling device
Device could cut HVAC energy use by nearly 20% in the US. Engineers at Duke University have demonstrated a dual-mode heating and cooling device for building climate control that, if…
Scientists solve big limitation of stratospheric balloon payloads
How do you cool a large telescope to absolute zero while flying it from a huge balloon at 130,000 feet? Nearly all photons emitted after the Big Bang are now…