Atrial fibrillation: New marker for atrial damage discovered

Privatdozent Dr. Markus Krane, Deputy Director of the Cardiac and Vascular Surgery Unit at the German Heart Center Munich, Clinic at Technical University of Munich (TUM) Andreas Heddergott / Technical University of Munich

Atrial fibrillation leads to a persistent irregular – often accelerated – heartbeat. While the condition is not life-threatening, if left untreated it can lead to serious complications such as stroke or heart failure.

It is caused by areas of the heart that hinder the normal conduction of electrical impulses so that the atrium no longer contracts rhythmically,” explains Professor Rüdiger Lange, Director of the Cardiac and Vascular Surgery Unit of the German Heart Center Munich.

Ablation is a procedure in which specific regions of the atrium are destroyed by applying heat or extreme cold to reroute the paths of electrical conduction and correct the abnormality.

Atrial protein as a potential biomarker

Two years ago, Privatdozent Dr. Markus Krane, Deputy Director of the Cardiac and Vascular Surgery Unit at the DHM und Professor Matthias Mann of the Max Planck Institute of Biochemistry compiled an Atlas of the Heart.

In the process, they discovered the protein myosin binding protein H-like (MYBPHL), which exists in two forms and exhibits an important characteristic: in humans, one of the forms, isoform 2, occurs only in the atria of the heart. Most other proteins in the heart, by contrast, are just as likely to occur in other cardiac regions as well.

The researchers therefore wondered whether MYBPHL might serve as a blood-borne marker for atrial tissue damage. “Markers are particularly important in cardiac medicine for predicting and assessing progress, because early recognition of problems in such a vital organ as the heart can save many lives,” says Markus Krane.

Elevated blood levels following injury

The scientists tested over a hundred blood samples from patients with atrial fibrillation in whom ablation had been performed. They found that levels of MYBPHL in the blood were highest immediately after ablation when the patients arrived at the intensive care unit and then gradually declined over the next 24 hours.

Patients who underwent cardiac valve surgery without atrial intervention, for example, did not show increased levels of the protein, which remained at the same levels as in the healthy control group.

“In this way we’re able to assess the extent of atrial damage and predict the patient’s progress by means of a simple blood test. This is only possible because the new marker has the considerable advantage that it is highly specific to atrial tissue. If levels of the new marker decrease while other markers for myocardial damage remain high, it can be assumed that other problems are at play, which we can then target early with additional tests and therapeutic measures,” says Krane.

Development of a rapid blood test planned

In the next step, Krane and his team plan to produce antibodies that only recognize isoform 2, which can then be used in a rapid blood test. Such a standardized test would be suitable for widespread routine use following surgical or interventional procedures that specifically target atrial tissue.

PD Dr. Markus Krane
Cardiac and Vascular Surgery Unit
German Heart Center Munich
Clinic at Technical University of Munich (TUM)
Phone: +49 (0) 89 1218 – 2503
krane(at)dhm.mhn.de

Harald Lahm, Martina Dressen, Nicole Beck, Stefanie Doppler, Marcus-André, Deutsch, Shunsuke Matsushima, Irina Neb, Karl Christian König, Konstantinos Sideris, Stefanie Voss, Lena Eschenbach, Nazan Puluca, Isabel Deisenhofer, Sophia Doll, Stefan Holdenrieder, Matthias Mann, Rüdiger Lange, Markus Krane: Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage, Scientific Reports, July 10, DOI: 10.1038/s41598-019-46123-w
https://www.nature.com/articles/s41598-019-46123-w

http://www.tum.de/nc/en/about-tum/news/press-releases/details/35595/ – This text on the web
http://www.dhm.mhn.de/de/kliniken_und_institute/klinik_fuer_herz-_und_gefaessc.c…
http://Cardiac and Vascular Surgery Unit of the German Heart Center Munich
http://www.dhm.mhn.de/de/kliniken_und_institute/klinik_fuer_herz-_und_gefaessc/k… – PD Dr. Markus Krane
https://mediatum.ub.tum.de/1515114 – Download high resolution image

Media Contact

Dr. Ulrich Marsch Technische Universität München

Alle Nachrichten aus der Kategorie: Life Sciences

Articles and reports from the Life Sciences area deal with applied and basic research into modern biology, chemistry and human medicine.

Valuable information can be found on a range of life sciences fields including bacteriology, biochemistry, bionics, bioinformatics, biophysics, biotechnology, genetics, geobotany, human biology, marine biology, microbiology, molecular biology, cellular biology, zoology, bioinorganic chemistry, microchemistry and environmental chemistry.

Zurück zur Startseite

Kommentare (0)

Schreib Kommentar

Neueste Beiträge

Simplified method to modify disease signaling with light

Most diseases are caused by aberrant cell signaling processes and basic research in cell signaling is needed to identify targets for future therapeutic approaches, especially in cases where no cures…

Highly selective membranes

Researchers discover how water can affect its own filtration. Membranes with microscopic pores are useful for water filtration. The effect of pore size on water filtration is well-understood, as is…

Interactions within larger social groups can cause tipping points in contagion flow

The distribution of group interactions in a social network affects the critical point at which explosive jumps in opinion, popularity, or disease spread occur. Contagion processes, such as opinion formation…

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close