Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Typ I Interferon receptor deficient mice for analysing immunological diseases

12.09.2012
<strong>Bckground</strong><br>

Interferons play a vital role in the natural response on viral infection. In particular, type I interferon (IFN-I) is the focus of interest in the development of new therapeutic approaches for example in the fields of immunology, tumor diseases, multiple sclerosis and sepsis. </p> <strong>Technology</strong><br> Two novel transgenic mice have been developed, the IFNAR knock-out mouse (IFNARKO) and the conditional IFNAR mouse (IFNARCOND), both congenic on the C57BL/6 background, the mouse type from which most of the tumors used in tumor models are isolated. The IFNARKO mouse carries an ubiquitous deletion of the interferon type I receptor (IFNAR) allowing investigations into the role of IFNAR in every tissue and every stage of development. The conditional IFNAR-mouse allows the potential IFNAR inactivation by an adequate stimulus in a specific tissue or cell type. By this, the function of the IFN-I system can be investigated in its spatial and temporal dimensions for the first time by targeted time- and/or site-controlled IFNAR inactivation.<br><br>

<p><strong>Benefits</strong> <ul> <li>Both mice are congenic (IFNARKO :20x crossed back; IFNARCOND :10x crossed back) on the C57BL/6 background (tumor mice)</li> <li>IFNARCOND based on Dupont’s Cre/loxP technology</li> <li> Big variety of transgenic mice regulating expression of the recombinase Cre in different cell types or tissues allows production of almost any kind of IFNAR deletion types.</li> </ul> <p><strong>IP Rights</strong><br> German Utility Models<br> IFNAR-KO No. 202004019129.6<br> IFNAR-COND No. 202004019128.8 </p> <p><strong>Origin</strong><br> Breeding took place at the Paul-Ehrlich-Institute (PEI) following GLP standard.</p> <p> </p>

Further Information: PDF

ipal GmbH
Phone: +49 (0)30/2125-4820

Contact
Dr. Dirk Dantz

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2740&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>