Targeted retrieval of recombinase activity by trans-splicing
The Cre/lox system constitutes a method for the site-directed recombination of nucleic acids, in which the enzyme Cre-recombinase achieves recombination of DNA at specific target sequences, the so-called loxP-sites. In this process the activity of the Cre-recombinase is dependent on the control of a cell-specific promotor. This method presently is applied in great variety for systematic mutagenesis, for example for the generation of gene-knockouts in mice-models.
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