Small Molecule XIAP Inhibitor
Apoptosis is a highly conserved process regulating the balance between cell death and proliferation for the maintenance of tissue homeostasis. Inhibitor of apoptosis proteins (IAPs) are a group of antiapoptotic proteins that
inhibit caspases, central players in the apoptotic cascade. <p> XIAP, the most potent and well characterized member of the IAP family is an inhibitor of caspase-3, -7 and -9. Through virtual screening of commercially available databases several compounds were identified as novel XIAP inhibitors. These compounds, which showed no cytotoxicity on their own, were tested in a human leukaemia cell line stably overexpressing XIAP for their ability to overcome the cells’ chemoresistance. <p>In order to develop the full therapeutic potential of our XIAP inhibitors, we currently work on the underlying apoptosis signalling mechanisms, NMR binding studies, and towards an in vivo proof of principle.
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
Contact
Peer Biskup
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Making diamonds at ambient pressure
Scientists develop novel liquid metal alloy system to synthesize diamond under moderate conditions. Did you know that 99% of synthetic diamonds are currently produced using high-pressure and high-temperature (HPHT) methods?[2]…
Eruption of mega-magnetic star lights up nearby galaxy
Thanks to ESA satellites, an international team including UNIGE researchers has detected a giant eruption coming from a magnetar, an extremely magnetic neutron star. While ESA’s satellite INTEGRAL was observing…
Solving the riddle of the sphingolipids in coronary artery disease
Weill Cornell Medicine investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new…