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Anisometric particles for the pulmonary application of active agents

13.12.2006
Inhalation therapy provides any advantages in comparison to the oral or intravenous application of drugs Pharmaceutically active agents can very often be applied to the site of action in a more targeted manner by means of inhalation, whereby the dose can be reduced in comparison to other application formulations and side effects can be lowered.<br><br>

In many cases, particles of the active agent have to be packed within suitable carrier molecules. Carrier molecules known so far are mostly spherical, and this spherical nature prevents the particles from achieving certain lung areas.<br><br> By contrast, the invention at hand provides for procedures for the manufacturing of inhalable particles from biocompatible polymers that are not spherical, but anisometric. Furthermore, diameter and length are specifically adjustable, and the particles may feature structured surfaces and/or pore- or pearl-like recesses. Thus it is possible to produce particles which can be specifically deposited within particular lung areas and which release the active agent in a retarded manner.

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Dr. Peter Stumpf

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