Monoclonal Antibodies: Anti-human C5a Receptor (C5aR / CD88); anti-C5aR-pSer334 (PKC site) mAb
Scientists at the Georg-August-University Göttingen produced different monoclonal antibodies directed against phosphorylation sites of C5aR. Using these antibodies the activation state of C5aR can be directly measured in tissue or cultured cells.
Since the relevant epitope is known to be phosphorylated by Protein Kinase C (PKC), this principle can also be used to measure PKC activity or to screen for new PKC inhibitors. CD88 is expressed by peripherial blood granulocytes and monocytes. Binding of C5a (fragment of the complement factor C5) to CD88 leads to cellular activation, including chemotaxis.
Further Information: PDF
MBM ScienceBridge GmbH
Phone: (0551) 30724-151
Contact
Dr. Jens-Peter Horst
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Silicon Carbide Innovation Alliance to drive industrial-scale semiconductor work
Known for its ability to withstand extreme environments and high voltages, silicon carbide (SiC) is a semiconducting material made up of silicon and carbon atoms arranged into crystals that is…
New SPECT/CT technique shows impressive biomarker identification
…offers increased access for prostate cancer patients. A novel SPECT/CT acquisition method can accurately detect radiopharmaceutical biodistribution in a convenient manner for prostate cancer patients, opening the door for more…
How 3D printers can give robots a soft touch
Soft skin coverings and touch sensors have emerged as a promising feature for robots that are both safer and more intuitive for human interaction, but they are expensive and difficult…
