RBL-C5aR cell line
Scientists at the University of Göttingen developed a transfectant RBL-C5aR cell line which is able to express more than 1 million C5a receptors on its cell surface, showing a specific high Ca2+ signal. The generated RBL-cells express C5aR in a number of „flavours“ (FLAG-tagged, N-glycosilation deficient, phosphorylation-deficient, co-transfected with other GPCR). C5aR(CD88) binds to C5a, an important chemotactic protein, element of the biochemical cascade of the complement system. This cell line would make the development of a standardized assay easy, fast, reproducible and sensitive.
Further Information: PDF
MBM ScienceBridge GmbH
Phone: (0551) 30724-151
Contact
Dr. Jens-Peter Horst
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Bringing bio-inspired robots to life
Nebraska researcher Eric Markvicka gets NSF CAREER Award to pursue manufacture of novel materials for soft robotics and stretchable electronics. Engineers are increasingly eager to develop robots that mimic the…
Bella moths use poison to attract mates
Scientists are closer to finding out how. Pyrrolizidine alkaloids are as bitter and toxic as they are hard to pronounce. They’re produced by several different types of plants and are…
AI tool creates ‘synthetic’ images of cells
…for enhanced microscopy analysis. Observing individual cells through microscopes can reveal a range of important cell biological phenomena that frequently play a role in human diseases, but the process of…