Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

PsymPed - Novel biotechnological synthesis of psymberin and pederin for the use as potent antitumor agents

13.10.2011
Natural products that elicit specific and unique biological responses in mammalian cells represent valuable tools for new therapeutics in the treatment of malignant diseases. The polyketides pederin and psymberin possess unique cytotoxic properties and are examples for very potent, highly selective and bioactive antitumor agents isolated from Peaderus beetles and different sea sponges. The substances are produced by bacterial symbionts that live in these organisms, but cannot be cultivated outside their hosts. As these compounds are received in very small quantities from each source, an alternative with high yield is desirable.

The localization and heterologous expression of bio-synthetic genes could further this issue and provide sufficient supplies for several pharmaceuticals. However, identification of the according genes in the usually highly complex symbiont communities remains a challenging task. The present inventions are based on the isolation of putative genes responsible for the production of pederin and psymberin. The so-derived genes could be trans-ferred to easily culturable bacteria to produce the antitumor polyketides in an ecologically sustainable manner and in theoretically unlimited amounts.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=2510&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Bifacial Stem Cells Produce Wood and Bast

Heidelberg researchers study one of the most important growth processes on Earth

So-called bifacial stem cells are responsible for one of the most critical growth processes on Earth – the formation of wood.

Im Focus: Energizing the immune system to eat cancer

Abramson Cancer Center study identifies method of priming macrophages to boost anti-tumor response

Immune cells called macrophages are supposed to serve and protect, but cancer has found ways to put them to sleep. Now researchers at the Abramson Cancer...

Im Focus: Ten-year anniversary of the Neumayer Station III

The scientific and political community alike stress the importance of German Antarctic research

Joint Press Release from the BMBF and AWI

The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...

Im Focus: Ultra ultrasound to transform new tech

World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles

The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.

Im Focus: Flying Optical Cats for Quantum Communication

Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.

In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Our digital society in 2040

16.01.2019 | Event News

11th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Aachen, 3-4 April 2019

14.01.2019 | Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

 
Latest News

Graphene and related materials safety: human health and the environment

23.01.2019 | Materials Sciences

Blood test shows promise for early detection of severe lung-transplant rejection

23.01.2019 | Life Sciences

Evolution of signaling molecules opens door to new sepsis therapy approaches

23.01.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>