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Protein RPS19 for the treatment of inflammatory diseases and cancer

06.05.2009
With respect to both structure and function, the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) is a unique mediator of the immune system, whose important role in inflammatory diseases such as septic shock, chronic inflammations and autoimmune diseases such as arthritis, glomerulonephritis, autoimmune encephalitis, and autoimmune diabetes is well known. In this context, the chemotactic effect of MIF on monocytes is an important step of the inflammatory cascade, which is mediated by a binding of MIF to the chemokine receptors CXCR2 and CXCR4.<br>

Our scientific studies now showed for the first time that the ribosomal protein S19 (symbol: RPS19, HGNC ID:10402) is able to inhibit the pro-inflammatory effect of the central mediator of inflammation, the macrophage migration inhibitory factor (MIF), in a receptordependent manner. Further in vitro experiments confirm an interaction of MIF with RPS19.

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