Peptides for inhibition of the HPV-E6 oncoprotein
Human papilloma viruses (HPVs) are associated
with various tumors in humans. Specific HPV types (most commonly HPV16) cause cervical cancer, Here, the continuous expression of the viral E6 and E7 oncogenes is essential to maintain the tumorigenic phenotype. One major function of the viral E6 protein is to mediate degradation of the tumorsuppressor protein p53. By blocking apoptosis, this activity is crucial both for tumor formation and for the therapeutic resistance of HPV-positive cancer cells. The peptides identified by our inventors block the intracellular activity of the HPV16 E6 protein and thus increase sensitivity of tumor cells towards apoptosis. This effect is highly specific for HPV16- containing tumor cells.
Further Information: PDF
DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
Phone: +49-6221-42 2955
Contact
Dr. Ruth Herzog
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Bringing bio-inspired robots to life
Nebraska researcher Eric Markvicka gets NSF CAREER Award to pursue manufacture of novel materials for soft robotics and stretchable electronics. Engineers are increasingly eager to develop robots that mimic the…
Bella moths use poison to attract mates
Scientists are closer to finding out how. Pyrrolizidine alkaloids are as bitter and toxic as they are hard to pronounce. They’re produced by several different types of plants and are…
AI tool creates ‘synthetic’ images of cells
…for enhanced microscopy analysis. Observing individual cells through microscopes can reveal a range of important cell biological phenomena that frequently play a role in human diseases, but the process of…
