So far, glycopeptides are mostly obtained from natural sources. However, purification of said peptides is highly challenging and laborious. The glycopeptides found in nature are mostly proteins of more than 100 amino acids in length, often comprising more than one glycosylation site(s) and their glycosylation pattern cannot be fully controlled. Therefore, there is still the need for efficient methods for producing glycopeptides by synthetical means. Currently, there are two common strategies for the chemical synthesis of glycopeptides known in the art. According to the first strategy, a peptide strand is synthesized and, during the synthesis of said peptide, one or more glycosylated amino acid building block(s) are integrated in the sequence instead of standard amino acids. According to the second strategy, a peptide is first fully synthesized, then, subsequently, one or more protecting groups are cleaved off selectively and the carbohydrate building block is conjugated to the peptide. Both strategies bear several severe drawbacks. The present invention relates to a method for the production of glycosylated peptides conjugated with one or more hydrophilic polymer(s) and glycosylating the polymer-conjugated peptide by means of one or more glycosyltransferase(s).
Further Information: PDF
Phone: +49 (0)208/94105 10
Dipl.-Ing. Alfred Schillert
firstname.lastname@example.org | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences