Compatibility of light detection with PET has been accomplished by developing an optical detector that consists of a 25 mm x 100 mm photon sensor (liquid cooled) for light detection, a microlens array for field-of-view definition, a septum masks for cross-talk suppression, and a transferable filter for wavelength selection. The instrument has been evaluated regarding ist optical performance and was successfully used in a number of preclinical studies such as simultaneous positron (18F-FDG, 68Ga-RGD) - bioluminescence (PC-3-hVEGF-Luc) imaging of reporter gene expression and receptor targeting in mice or simultaneous imaging of fluorescent XenoLight-RediJect-2-DG-750 and radio-labeled FDG probes.
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