Nuclear export inhibitors with anti-tumoral and anti-viral activity
Regulated nucleo-cytoplasmic transport of pathobiologically relevant proteins is critical for tumor development and viral diseases. Transport is mediated by nuclear export signals (NESs) interacting with the export receptor CRM1. NESs have been identified in numerous disease relevant cellular and viral proteins. Hence, the pharmacogenetic interference with nuclear export provides an attractive and novel therapeutic principle to rationally control and target the activity of such disease factors. This invention now provides three novel nuclear export inhibitors (NEIs) with shown anti-tumoral and antiviral activity. As such, these drugs may represent a hitherto neglected additional pillar for combination treatment of human diseases.
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