New inhibitor of miR-24 for the treatment of ischemia

The invention shows the use of miR-24 modulation to interfere with angiogenic signalling in vitro and in vivo. MiR-24 is triggering endothelial cell (EC) apoptosis via a signal cascade involving the mediators GATA2, PAK4 and others. This is also accompanied by a deficient angiogenic response. MiR-24 antagonism can block these detrimental effects. In a murine model of myocardial infarction (MI) reflecting ischemic disease, miR-24 expression is enhanced specially in cardiac ECs. Following MI, therapeutic intervention with a miR-24 specific antagonist lowered endogenous miR-24, preserved cardiac function and improved capillary density. The same pro-angiogenic effects were seen when implanting matrigel plugs to mice after treatment with miR-24 inhibitors. Thus, therapeutic knockdown of miR-24 is beneficial for cardiac performance upon MI and likely many other ischemic diseases. Collectively, miR-24 modulation can be useful in different settings of ischemic disease to sustain vasculature. As we have investigated therapeutic miR-24 intervention upon MI and in implanted matrigel plugs, we conclude that our results can be transferred to other ischemic stress models like hindlimb ischemia (peripheral occlusive disease), ischemic gut diseases, ischemia of virtually all organs such as kidney, liver, brain, spleen, dermal tissue, lung and others. In addition surgical operations and organ transplantation often result in ischemia-triggered organ function, which could be a target of miR-24 inhibitory therapies.

Further information: PDF

Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0

Contact
Peer Biskup

As Germany's association of technology- and patenttransfer agencies TechnologieAllianz e.V. is offering businesses access to the entire range of innovative research results of almost all German universities and numerous non-university research institutions. More than 2000 technology offers of 14 branches are beeing made accessable to businesses in order to assure your advance on the market. At www.technologieallianz.de a free, fast and non-bureaucratic access to all further offers of the German research landscape is offered to our members aiming to sucessfully transfer technologies.

Media Contact

info@technologieallianz.de TechnologieAllianz e.V.

All latest news from the category: Technology Offerings

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors