Nanoparticle based on reactive Polypeptides

There are no basic technologies for nano-particles available, which are suitable for medical application. The present invention offers such a new technology, which is deal-ing with a bifid copolypeptide consisting of one hydrophilic polysarcosine and one hy-drophobic polycysteine part. The hydrophilic polysarcosine part prevents an unspecific binding on proteins, increases the solubility in the serum, and no immune reaction will be activated. Thus it is an ideal protection for encapsulated drugs.
The polycysteine part forms autonomous micelles in polar solvents, which are stabi-lized by cross linked disulphide bridges. The resulting micelles are stable in blood, in the cytosol, against glutathione and also survive endocytosis of antigen presenting cells or macrophages.
When the disulfide bonds were cleaved by metabolization, the copolymer loses its sta-bility and the active ingredient will be re-leased.

[Reference UMZ314]

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