MMPace – a novel screening assay for MMP-Inhibitors

An innovative cell based MMP bioassay was invented enabling high through-put screening of novel MMP inhibitors. The method is based on the heterologous expression and immobilization of biologically active forms of MMP 2 and MMP 9 on the cell surface of Pichia pastoris via a novel, highly efficient cell surface display system. Yeast cells modified in this way can either be provided as fresh cells or freeze-dried, enabling their direct use in MMP inhibitor screenings.

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Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
Phone: +49 (0)681/302-71302

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Dipl.-Kfm. Axel Koch (MBA), Dr. Conny Clausen, Dr. Hauke Studier, Dr. Susanne Heiligenstein

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