MMPace – a novel screening assay for MMP-Inhibitors

A wide range of human diseases, such as diabetes mellitus, arthritis and, most of all, cancer, goes along with malfunctions in the regulation of matrix metalloproteinases, especially MMP 2 and MMP 9. In view of this background, an innovative cell based MMP bioassay was invented enabling high through-put screening of novel MMP inhibitors. The method is based on the <b>heterologous expression and immobilization of biologically active forms of MMP 2 and MMP 9</b> on the cell surface of Pichia pastoris via a novel, highly efficient cell surface display system. Therefore now a source for MMP without further activation is available plus MMPs are produced in a host that posesses GRAS status.

Further Information: PDF

Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
Phone: +49 (0)681/302-6340

Contact
Dipl. Chem. Dagmar Vössing, Dipl.-Kfm. Axel Koch MBA, Dipl. Ing. Gerd Schneider

Media Contact

info@technologieallianz.de TechnologieAllianz e.V.

All latest news from the category: Technology Offerings

Back to home

Comments (0)

Write a comment

Newest articles

The Sound of the Perfect Coating

Fraunhofer IWS Transfers Laser-based Sound Analysis of Surfaces into Industrial Practice with “LAwave”. Sound waves can reveal surface properties. Parameters such as surface or coating quality of components can be…

Customized silicon chips

…from Saxony for material characterization of printed electronics. How efficient are new materials? Does changing the properties lead to better conductivity? The Fraunhofer Institute for Photonic Microsystems IPMS develops and…

Acetylation: a Time-Keeper of glucocorticoid Sensitivity

Understanding the regulatory mechanism paves the way to enhance the effectiveness of anti-inflammatory therapies and to develop strategies to counteract the negative effects of stress- and age-related cortisol excess. The…

Partners & Sponsors