The invention provides a new adjuvant free vaccination strategy for the treatment or prev ention of neurodegenerative diseases like Alzheimer’s disease (AD), which is known to be the most common form of dementia. <br> The inventors developed retrovirus-like particles who present the N-terminus (1-15) of the human amyloidal beta 42-peptide on their surface. The present-ed epitope causes a strong and sustained B- but no T-cell response after single immunization in mice and can therefore be used as immunization agent. Furthermore, the vaccination showed a significant decrease of amy-loidal plaque load and soluble and insoluble cerebral Aß40/42 concentration in APP23 mouse model for AD. <br> First experiments in an Alzheimer’s disease mouse model proofed that immu-nization with the new developed particles induces a high anti-Aß-immu-noglobulin serum titer and reduces the number as well as the spreading of amyloid beta deposits in the mouse brain. </p> <p><strong>Benefits</strong><br>
firstname.lastname@example.org | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
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New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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