The invention provides a new adjuvant free vaccination strategy for the treatment or prev ention of neurodegenerative diseases like Alzheimer’s disease (AD), which is known to be the most common form of dementia. <br> The inventors developed retrovirus-like particles who present the N-terminus (1-15) of the human amyloidal beta 42-peptide on their surface. The present-ed epitope causes a strong and sustained B- but no T-cell response after single immunization in mice and can therefore be used as immunization agent. Furthermore, the vaccination showed a significant decrease of amy-loidal plaque load and soluble and insoluble cerebral Aß40/42 concentration in APP23 mouse model for AD. <br> First experiments in an Alzheimer’s disease mouse model proofed that immu-nization with the new developed particles induces a high anti-Aß-immu-noglobulin serum titer and reduces the number as well as the spreading of amyloid beta deposits in the mouse brain. </p> <p><strong>Benefits</strong><br>
firstname.lastname@example.org | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.
The scientific and political community alike stress the importance of German Antarctic research
Joint Press Release from the BMBF and AWI
The Antarctic is a frigid continent south of the Antarctic Circle, where researchers are the only inhabitants. Despite the hostile conditions, here the Alfred...
World first experiments on sensor that may revolutionise everything from medical devices to unmanned vehicles
The new sensor - capable of detecting vibrations of living cells - may revolutionise everything from medical devices to unmanned vehicles.
Dead and alive at the same time? Researchers at the Max Planck Institute of Quantum Optics have implemented Erwin Schrödinger’s paradoxical gedanken experiment employing an entangled atom-light state.
In 1935 Erwin Schrödinger formulated a thought experiment designed to capture the paradoxical nature of quantum physics. The crucial element of this gedanken...
Cellulose obtained from wood has amazing material properties. Empa researchers are now equipping the biodegradable material with additional functionalities to produce implants for cartilage diseases using 3D printing.
It all starts with an ear. Empa researcher Michael Hausmann removes the object shaped like a human ear from the 3D printer and explains:
The phenomenon of so-called superlubricity is known, but so far the explanation at the atomic level has been missing: for example, how does extremely low friction occur in bearings? Researchers from the Fraunhofer Institutes IWM and IWS jointly deciphered a universal mechanism of superlubricity for certain diamond-like carbon layers in combination with organic lubricants. Based on this knowledge, it is now possible to formulate design rules for supra lubricating layer-lubricant combinations. The results are presented in an article in Nature Communications, volume 10.
One of the most important prerequisites for sustainable and environmentally friendly mobility is minimizing friction. Research and industry have been dedicated...
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