The invention describes a method and device to monitor cellular activity and vitality with higher accuracy than common methods. This method is based on measuring the specific cellular form and its development. To do so, several parameters are created, which interact with the neighbour cells and which are comparable over the course of the monitoring. The monitoring is done by recording the cellular movement and growth by video recording through a microscope. At the start of the compatibility testing, the substrate or material and the cells are brought together and get monitored over the course of 4 to 12 hours. All changes to the cells get recorded via video. After this, the entirety of the movement data from the cells is compared with reference data from tests with similar substrates. By doing so the invention delivers infor-mation about effect and toxicity of the tested substrate or material.
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