Low toxic agents for treatment of B-Cell Lymphomas and Leishmaniasis
Search for novel natural products from the extracts of various parts of plants is still an important pillar of modern drug research. Plants of the families Dioncophyllaceae and Ancistrocladaceae are the only producers of Naphtho¬quinones. These novel lead candidates can be used as antitumoral agents for the treatment of B-cell lymphoma or multiple myeloma and as antiinfectives against malaria, African sleeping sickness, Chagas disease or leishma¬niasis.
<p> The novel lead substances can be used as antitumoral agents for the treatment of B-cell lymphoma or multiple myeloma. In vitro tests prove significantly reduced cell poliferation in tumor cell lines of aggressive B-Cell lymphomas as well as MM whereas they are non-toxic against normal peripheralmono-nuclear blood cells. <p> The compounds are attractive leads for the treatment of multiple myeloma which is the second most frequent hematological form of tumor and offer an alternative to the anti-CD20 treatment strategies. <p>
Further Information: PDF
Bayerische Patentallianz GmbH
Phone: +49 89 5480177-0
Contact
Peer Biskup
Media Contact
All latest news from the category: Technology Offerings
Newest articles
High-energy-density aqueous battery based on halogen multi-electron transfer
Traditional non-aqueous lithium-ion batteries have a high energy density, but their safety is compromised due to the flammable organic electrolytes they utilize. Aqueous batteries use water as the solvent for…
First-ever combined heart pump and pig kidney transplant
…gives new hope to patient with terminal illness. Surgeons at NYU Langone Health performed the first-ever combined mechanical heart pump and gene-edited pig kidney transplant surgery in a 54-year-old woman…
Biophysics: Testing how well biomarkers work
LMU researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy. Modern microscopy techniques make it possible to examine the inner workings…
