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Innovatives Verfahren zur industriellen Herstellung von Aptameren

05.06.2014

Aptamers are short, single-stranded DNA molecules that can specifically bind proteins due to their three-dimensional structure. Because of their ability to deactivate different protein functions inside the cell, aptamers are already used successfully in the field of medical diagnosis, as therapeutic agents and in environmental analytics. So far the technical production of single stranded DNA (ssDNA) within the range of more than 60 n has been linked to a grand percentage of abbreviated respectively functionless by-products. Bigger aptamers with even 100 n or more have only been practicable facing great loss of quantity of material. Within the case of aptamers, an exact sequence identity is essential for technical application, though. By use of the described technology it is now possible to produce aptamers in the range of 100 n and beyond in unmatched quality and quantity via a multi-copy-fragment (“AptaGENE”), using a combination of both in vitro and in vivo techniques. [Reference UKL221]

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