Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

HypoPlant - Production of hypo-allergenic glycoproteins in plants

02.12.2010
Glycoproteins (GPs) are of prime interest in medical sci-ence. However, the production of GPs by standard methods is still complex and expensive. Plants have been suggested as potential cost-effective and safe GP-production systems; however, major differences in the final steps of biosynthetic pathways in mammals and plants lead to different glycosylation patterns, provoking an immune response when treating humans with GPs produced in plants.

Challenge State-of-the-art approaches utilize glycosylation mutants or overexpression of the desired protein product (intending to override the cellular glycosylation machinery), although such mutants either show impaired yield or loss of vitality in com-parison to wild type. Also, rarely glycan components termi-nate in mannose residues, which is essential for uptake via mannose receptors in patients with lysosomal storage dis-eases. This invention provides a new tool to generate GPs with hypo-allergenic properties in a cost-effective way: In con-trast to current methods, the new technique enables effec-tive production of heterologous GPs by vital plants without impair¬¬ments. The technology is based on genetic modifica-tion of the plant glycosylation pathway. The technology is applicable to Solanaceous and other plants of agronomical interest. Suppression of a specific enzyme results in a general reduction of cross-reactive car-bohydrate determinants (CCD) in all tissues, leading to GPs that are better tolerated and taken up by humans.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=1443&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Massive impact crater from a kilometer-wide iron meteorite discovered in Greenland

15.11.2018 | Earth Sciences

When electric fields make spins swirl

15.11.2018 | Physics and Astronomy

Discovery of a cool super-Earth

15.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>