Autoantibodies (autoAB) against the insulin receptor (IR) are known to cause a rare form of diabetes, i.e. insulin resistance type B. AutoAB against the structurally and functionally related receptor for insulin-like growth factor-1 (IGF1R) have only recently been described and are implicated in autoimmune diseases. However, the prevalence and clinical importance of these autoAB are not yet fully understood as respective sensitive and non-radioactive test systems for routine use were missing. A reliable assay system for the detection and quantification of these autoAB should be met with highest interest by basic researchers and clinicians alike, especially in the fields of diabetes, growth and cancer research, given the central importance of the insulin and IGF1 hormone axes for controlling growth, glucose metabolism and cell proliferation in humans.<br><br> <strong>Technology</strong><br> Two novel non-radioactive and highly sensitive immunoassays for detection and quantification of autoAB against the IR and IGF1R have been developed. For reasons of sensitivity, specificity and automation, the bridge technology has been chosen as most suitable assay format (see scheme). Using these novel in vitro diagnostica, autoAB against the IR and the IGF1R are detected with an astonishing 10% prevalence in the adult population. Notably, a high proportion of cross-reacting autoAB are found, reacting with similar strength to both the IR and IGF1R. The clinical and diagnostic importance of these results remains to be established in ongoing studies.<br><br>
email@example.com | TechnologieAllianz e.V.
New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.
Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.
Adjusting the thermal conductivity of materials is one of the challenges nanoscience is currently facing. Together with colleagues from the Netherlands and Spain, researchers from the University of Basel have shown that the atomic vibrations that determine heat generation in nanowires can be controlled through the arrangement of atoms alone. The scientists will publish the results shortly in the journal Nano Letters.
In the electronics and computer industry, components are becoming ever smaller and more powerful. However, there are problems with the heat generation. It is...
Scientists have visualised the electronic structure in a microelectronic device for the first time, opening up opportunities for finely-tuned high performance electronic devices.
Physicists from the University of Warwick and the University of Washington have developed a technique to measure the energy and momentum of electrons in...
Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. The study was published in July in the Journal “Haematologica”.
Hematopoiesis is the process of forming blood cells, which occurs predominantly in the bone marrow. The bone marrow produces all types of blood cells: red...
For some phenomena in quantum many-body physics several competing theories exist. But which of them describes a quantum phenomenon best? A team of researchers from the Technical University of Munich (TUM) and Harvard University in the United States has now successfully deployed artificial neural networks for image analysis of quantum systems.
Is that a dog or a cat? Such a classification is a prime example of machine learning: artificial neural networks can be trained to analyze images by looking...
An international research group led by scientists from the University of Bayreuth has produced a previously unknown material: Rhenium nitride pernitride. Thanks to combining properties that were previously considered incompatible, it looks set to become highly attractive for technological applications. Indeed, it is a super-hard metallic conductor that can withstand extremely high pressures like a diamond. A process now developed in Bayreuth opens up the possibility of producing rhenium nitride pernitride and other technologically interesting materials in sufficiently large quantity for their properties characterisation. The new findings are presented in "Nature Communications".
The possibility of finding a compound that was metallically conductive, super-hard, and ultra-incompressible was long considered unlikely in science. It was...
24.06.2019 | Event News
29.04.2019 | Event News
17.04.2019 | Event News
19.07.2019 | Physics and Astronomy
19.07.2019 | Physics and Astronomy
19.07.2019 | Earth Sciences