High-throughput method for determining the presence of papillomavirus-neutralizing antibodies in a sample
The invention is based on papillomavirus pseudovirions consisting of L1 and L2 proteins encapsulating Gaussia luciferase as a reporter system. Using HeLaT K4 cells as target cells the screen can be performed in a high-throughput format without the need of time consuming manual pipetting steps. The method is validated and can be used for clinical studies generating approval-relevant data. Technology opportunities are non-exclusive licensing or service
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