Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Exosomes - Use of exosomes in prevention and therapy of acute inflammation associated diseases

19.06.2013
Exosomes are nano-sized, secreted cell organelles that are released by a huge variety of different cell species, including mesenchymal stem cells (MSCs). Containing a combination of lipids and proteins as well as RNAs, exosomes participate in intercellular communication processes.

Due to the wide range of molecules they enclose and their cell type specific assembly, these small membrane vesicles get more and more in the focus of diagnosis, drug delivery and clinical applications. Some preliminary pre-clinical and clinical application of MSC-derived exosomes of scientists at the University Duisburg-Essen revealed very promising results (see below). However, coupled with the fact that beneficial effects of MSC administration are controversially discussed, it appears very likely that not all MSC-derived exosome fractions will exert beneficial effects. To select for MSC exosomes being able to efficiently suppress inflammation associated symptoms the scientists compared immune modulating activities of independent MSC-derived exosome preparations. Aiming to treat a 22-years female patient suffering from severe therapy-refractory cutaneous and intestinal Graft-versus-Host Disease (GvHD) grade IV with MSC-derived exosomes, the scientists administered exosomes which revealed the strongest immune-suppressive effects in vitro. The documentation of the impacts on the clinical symptoms and the immune response showed that the selected MSC exosome preparation helped to suppress GvHD symptoms in vivo. Since the in vivo administration appears to be safe, MSC exosome administration of selected preparations turned out to be a promising new treatment option in the prevention and therapy of diseases associated with acute inflammatory processes, such as GvHD, stroke, heart-attack and neonatal damages of the brain and lungs.

Further Information: PDF

PROvendis GmbH
Phone: +49 (0)208/94105 10

Contact
Dipl.-Ing. Alfred Schillert

info@technologieallianz.de | TechnologieAllianz e.V.
Further information:
http://www.technologieallianz.de/angebote.php?sort=sag&id=3166&lang=en
http://www.technologieallianz.de

More articles from Technology Offerings:

nachricht New Lithium Salts of Pentafluorophenylamide Anions as Electrolytes in Lithium Ionic Batteries
18.04.2017 | TechnologieAllianz e.V.

nachricht Gratings on glass surfaces
28.03.2017 | TechnologieAllianz e.V.

All articles from Technology Offerings >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Massive impact crater from a kilometer-wide iron meteorite discovered in Greenland

15.11.2018 | Earth Sciences

When electric fields make spins swirl

15.11.2018 | Physics and Astronomy

Discovery of a cool super-Earth

15.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>