he novel radiolabeled exendin derivatives provide a highly specific diagnostic tool for the detection of beta cells in the pancreas of patients at risk of developing diabetes or already having diabetes. An imaging protocol has been developed that allows single time point quantitative SPECT/CT imaging to allow for simple, time-efficient clinical imaging. The product is ready-to-use for clinical applications and gives for the first time the opportunity for detection of changes in beta cell mass in persons with diabetes or at risk to develop the disease. The possibility of beta cell mass quantification is fur-thermore associated to the chance of validation of therapy success with already available medicaments or new drug candidates that may preserve or increase beta cell mass.
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