Complexation with polymeric excipient for improved water solubility
On the one hand, better water solubility of drugs leads to an improved bioavailability. Secondly, drug concentration for application can be decreased.
At Saarland University, a procedure has been developed that allows a significant enhancement of water solubility of compounds that are usually insoluble. The method combines the advantages of both known approaches – without showing their disadvantages. This can be attained by reversible complex formation of the active agents with a certain structural element which is approved for oral application. But simple blending of both components does not lead to an improved solubility. Only a combination of complex formation and freeze drying finally results in products that are water soluble. This approach allows it to produce active agent complexes showing an increased water solubility using standard procedures and prevalent chemicals.
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Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
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Dr. Annekathrin Seifert (Dipl.-Chem.), Dipl.-Kfm. Axel Koch (MBA), Dr. Hauke Studier (Dipl.-Phys.)
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