BCAT1 for the Diagnosis and Prognosis of Brain Tumors
Glioblastomas are the most common and most aggressive human malignant brain tumors. Treatment options for glioblastomas and other gliomas include neurosurgical techniques (resection or stereotactic procedures), radiation therapy and chemotherapy.
Knowledge of the diagnostic and prognostic fac-tors is crucial for the selection of the best form of life-prolonging therapy. Studies have shown that glioma patients harboring an isocitrate dehydrogenase (IDH) 1 or 2 mutation have a better prognosis compared to glioma patients with wild-type IDH1 and IDH2. DKFZ researchers have demonstrated that gliomas with increased (>3 fold compared to control) branched-chain aminotransferase 1 (BCAT1) expression do not harbor IDH1 or IDH2 mutations and thus have a poor prognosis. The present invention allows a fast and reliable diagnostic and prognostic classification of tumors based on the activity of branched-chain amino acid metabolism as reflected by the level or activity of BCAT1.
Further Information: PDF
Deutsches Krebsforschungszentrum DKFZ
Phone: +49-6221-42 2955
Contact
Dr. Ruth Herzog
Media Contact
All latest news from the category: Technology Offerings
Newest articles
High-energy-density aqueous battery based on halogen multi-electron transfer
Traditional non-aqueous lithium-ion batteries have a high energy density, but their safety is compromised due to the flammable organic electrolytes they utilize. Aqueous batteries use water as the solvent for…
First-ever combined heart pump and pig kidney transplant
…gives new hope to patient with terminal illness. Surgeons at NYU Langone Health performed the first-ever combined mechanical heart pump and gene-edited pig kidney transplant surgery in a 54-year-old woman…
Biophysics: Testing how well biomarkers work
LMU researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy. Modern microscopy techniques make it possible to examine the inner workings…
