The invention provides a novel predictive biomarker to help identify the patient population with the most favorable clinical outcome to angiogenesis-targeted treatment in mCRC patients. Experiments revealed that patients with low pretherapeutic Ang-2 serum levels receiving a bevacizumab-containing treatment were associated with a better Response rate compared to patients with high pretherapeutic Ang-2 levels. Additionally to a reduced risk of death (>90%) patients with low pretherapeutic Ang-2 levels showed a significant increase in progression-free survival (up to five months).
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