Allosteric activators and inhibitors of proteinkinases of the AGC- and the Aurora-family
Another new approach to influence protein kinases which is also part of this invention is the allosteric regulation of such enzymes.
A hydrophobe binding site on the surface of some protein kinases of the AGC-family was identified by analyzing their crystal structure. The invention includes some new classes of small molecule compounds which bind to and by allosteric effect influence the acitivity of protein kinases. The inventors were able to inhibit the kinase activity as well as to cause an activation of the kinase. Both were examined with several different protein kinase assays.
Further Information: PDF
Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
Phone: +49 (0)681/302-6340
Contact
Dr. Dipl. Chem. Anne Seifert, Dipl.-Kfm. Axel Koch MBA, Dipl.-Ing. Gerd Schneider
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Bringing bio-inspired robots to life
Nebraska researcher Eric Markvicka gets NSF CAREER Award to pursue manufacture of novel materials for soft robotics and stretchable electronics. Engineers are increasingly eager to develop robots that mimic the…
Bella moths use poison to attract mates
Scientists are closer to finding out how. Pyrrolizidine alkaloids are as bitter and toxic as they are hard to pronounce. They’re produced by several different types of plants and are…
AI tool creates ‘synthetic’ images of cells
…for enhanced microscopy analysis. Observing individual cells through microscopes can reveal a range of important cell biological phenomena that frequently play a role in human diseases, but the process of…
