AHSG Imaging – In-vivo imaging of calcified lesions
Pathological calcification and its detection is a topic relevant as well for basic research as for many clinical fields. For example, micro-calcification occurs in several kinds of tumours (e.g. in certain kinds of brain tumours, prostate – and breast cancer) and the detection is important for diagnostic and therapeutic purpose. Moreover pathological calcification is related to many rheumatic and nephrological diseases. Probably the most common disease associated with calcification is artherosclerosis.
The liver-derived serum protein Alpha2-HS Glycoprotein (AHSG / Fetuin-A) is one of the most important calciumbinding proteins involved in mineral homeostasis. It is considered to be a systemic inhibitor of calciumphosphate precipitation, thus preventing calcification. This invention relates to the use of AHSG and its derivatives for in-vivo detection of physiologic and pathologic calcification. After labeling with e.g. fluorescent or luminescent dyes, AHSG enriches in the calcified tissue and can be detected by different imaging modalities with very high sensitivity.
Further Information: PDF
PROvendis GmbH
Phone: +49 (0)208/94105 10
Contact
Dipl.-Ing. Alfred Schillert
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Superradiant atoms could push the boundaries of how precisely time can be measured
Superradiant atoms can help us measure time more precisely than ever. In a new study, researchers from the University of Copenhagen present a new method for measuring the time interval,…
Ion thermoelectric conversion devices for near room temperature
The electrode sheet of the thermoelectric device consists of ionic hydrogel, which is sandwiched between the electrodes to form, and the Prussian blue on the electrode undergoes a redox reaction…
Zap Energy achieves 37-million-degree temperatures in a compact device
New publication reports record electron temperatures for a small-scale, sheared-flow-stabilized Z-pinch fusion device. In the nine decades since humans first produced fusion reactions, only a few fusion technologies have demonstrated…
