A novel pH-biosensor for magnetic resonance imaging and spectroscopy

pH-biosensors based on compounds with pH-sensitive enolic groups for magnetic resonance imaging and spectroscopy and their uses. Possible medical applications for pH imaging with this new pH sensor are extremely numerous since many pathologies cause changes in pH. Good examples are tumors, inflammation and ischemia. Furthermore, the application as a very precise pH sensor for in vitro NMR-spectroscopy is possible, e.g. for response-to-treatment monitoring of treatments applied to cell lines.

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