An estimated 17% of human cancers are caused by chronic infection. Cancer results from the progressive accumulation of genetic changes to the body’s healthy regulation of cell growth. It arises when these changes cause cells to proliferate uncontrollably. The International Agency for Research on Cancer recognizes 9 viral and bacterial agents that appear to provoke this biological chain of events.
“INCA will help researchers develop new prevention measures and treatments against cancers such as leukemia, stomach cancer, and cervical cancer”, explained Professor Thomas Schulz, INCA’s principal coordinator based at Hannover Medical School, Germany. The consortium will focus on five viruses and one bacterium, the gut-dwelling Helicobacter pylori, to investigate how chronic infections and inflammation can interfere with normal cellular functioning.
Techniques like gene expression profiling reveal 100’s or even thousands of genes that are apparently active in a particular disease state. Such results require specialized statistical processing. INCA will exploit existing biological knowledge of inflammatory pathways to interpret high throughput data measuring transcriptomic, proteomic and metabolomic activity. Professor Schulz added, “Genedata’s informatics resources will help us gain the best advantage from genome-wide experimental investigations”.
“We are proud to provide the research informatics infrastructure for this important cancer research program”, says Dr. Othmar Pfannes, CEO of Genedata AG. Genedata will integrate high throughput molecular data and provide quantitative data analysis and training services. Dr. Pfannes added, “Our computational solutions are tailored for collaborative settings and provide a valuable informatics foundation for consortia-based research efforts”.
Tobe Freeman | alfa
How Humans and Machines Navigate Complex Situations
19.11.2018 | Max-Planck-Institut für Bildungsforschung
A gene activated in infant and young brains determines learning capacity in adulthood
13.11.2018 | Universitätsklinikum Hamburg-Eppendorf
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
14.12.2018 | Power and Electrical Engineering
14.12.2018 | Physics and Astronomy
14.12.2018 | Physics and Astronomy