Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Infra red spotlights crystal growth

19.01.2009
The creation of a reproducible crystallisation process is a fundamental challenge to drug manufacturers, but a technique which provides real time detailed analyses of chemical processes could provide an answer.

Developed by engineers at the University of Leeds, the technique uses infra-red spectroscopy to monitor supersaturation – the levels of chemical saturation in a liquid - required for crystallisation to begin to occur.

Most drug compounds are crystalline, manufactured in batch process systems. Small changes in crystallisation process conditions, such as temperature and cooling rates, can significantly affect the structure of the resulting crystals, something which affects both their physical properties and their performance.

“For example, when you cool water the molecules in the water have to get into the right position to begin crystallising into ice crystals and the temperature can have a bearing on the size of ice crystals that are formed,” says Dr Tariq Mahmud from the University’s School of Process, Environmental and Materials Engineering. “It’s similar with chemicals, although there’s a wider range of parameters to take into account.”

The new technique uses a probe attached to an infra-red spectrometer to measure the concentration of a specific chemical in solution. In laboratory experiments, this technique was used on the batch cooling crystallisation of chemical L-Glutamic acid (LGA). The information gained from the infra-red spectrometer is coupled with detailed statistical – or chemometric - data to provide a more detailed analysis of the crystallisation process than has been possible with other infra-red spectrometry techniques.

Dr Mahmud explains: “Using a chemometric approach enables us to take many more parameters into account, which makes it a more reliable predictor of the optimum concentration levels required to produce a particular crystal structure.”

The latest technique was developed by engineers at Leeds in collaboration with researchers at Newcastle and Heriot-Watt universities as part of the Chemicals Behaving Badly programme which is funded by the Engineering and Physical Sciences Research Council, along with ten industrial partners.

It is the latest in a raft of new “Quality by Design” (QBD) tools being developed for the pharmaceutical manufacturing sector as part of a drive for increased understanding of drug processing fundamentals. “By developing tools to increase knowledge about, and monitor, batch process systems, we’re providing practical solutions to problems faced by industry on a daily basis,” says Dr Mahmud. “This sort of technological approach to manufacture will help reduce waste – and therefore costs - and could have a significant role to play in increasing the competitiveness of the pharmaceutical sector.”

Clare Elsley | alfa
Further information:
http://www.leeds.ac.uk
http://www.leeds.ac.uk/media/press_releases/current09/infrared.htm

More articles from Process Engineering:

nachricht New technology for ultra-smooth polymer films
28.06.2018 | Fraunhofer-Institut für Organische Elektronik, Elektronenstrahl- und Plasmatechnik FEP

nachricht Diamond watch components
18.06.2018 | Schweizerischer Nationalfonds SNF

All articles from Process Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Global study of world's beaches shows threat to protected areas

19.07.2018 | Earth Sciences

New creepy, crawly search and rescue robot developed at Ben-Gurion U

19.07.2018 | Power and Electrical Engineering

Metal too 'gummy' to cut? Draw on it with a Sharpie or glue stick, science says

19.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>