To better understand the role complex tumor-host interactions play in tumor growth, Princeton University researchers developed a cellular automation model for tumor growth in heterogeneous microenvironments. They then used this same model to investigate the effects of pressure on the growth of a solid tumor in a confined heterogeneous environment, such as a brain cancer growing in the cranium, and discovered that pressure accumulated during tumor growth can lead to a wide spectrum of growth dynamics and morphologies for both noninvasive and invasive tumors.
Depending on the magnitude of the pressure and the physical properties of the host environment, the types of tumor patterns that emerge range from strongly malignant tumors characterized by finger-like protrusions at the tumor surface to those in which fingering growth is diminished. These results should have important applications for cancer diagnosis, prognosis, and therapy.
Article: "Diversity of dynamics and morphologies of invasive solid tumors" is published in AIP Advances.
Authors: Yang Jiao (1) and Salvatore Torquato (1,2,3,4,5).(1) Physical Science in Oncology Center, Princeton University, N.J.
Charles E. Blue | EurekAlert!
The taming of the light screw
22.03.2019 | Max-Planck-Institut für Struktur und Dynamik der Materie
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Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.
"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...
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