Today the European Molecular Biology Laboratory (EMBL) opens a new high-throughput crystallization facility at its Outstation located on the campus of the German Synchrotron Radiation Facility (DESY) in Hamburg, Germany. The facility, made possible by major funds from the German Ministry for Science and Education (BMBF), will combine technological advances in new ways to transform proteins into crystals, a key step in efforts to automate the process of analyzing protein structures. “We’re very grateful to the BMBF and the European Union for supporting the initiative, and thus providing an important service to the European life sciences community,” says EMBL Director General Iain Mattaj.
Structural biologists attempt to understand how proteins perform their many functions by determining their three-dimensional structures by X-ray crystallography. The method has been revolutionized by the use of the most powerful sources of X-rays around the world, such as the synchrotron at DESY. EMBL offers scientists throughout Europe access to instruments at DESY and at the ESRF in Grenoble, France.
The atomic structures of biological molecules can provide key information, for example, showing how they assemble into large complexes or how their function can be inhibited by drugs. However, getting proteins into crystal form is still a major bottleneck and a time-consuming step. “It can take researchers several thousand trials to successfully crystallize a protein,” says Jochen Müller-Dieckmann, head of the new facility. But while state-of-the-art synchrotron beamlines throughout Europe are available for use by the research community, there are almost no facilities with large capacities for crystallization. That will change with the new facility in Hamburg. Even prior to the official opening, scientists have shown a keen interest.
Sarah Sherwood | alfa
First evidence on the source of extragalactic particles
13.07.2018 | Technische Universität München
Simpler interferometer can fine tune even the quickest pulses of light
12.07.2018 | University of Rochester
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
13.07.2018 | Event News
13.07.2018 | Materials Sciences
13.07.2018 | Life Sciences