Researchers at the Harvard School of Engineering and Applied Sciences (SEAS) demonstrated a new type of optical tweezer with the potential to make biological and microfluidic force measurements in integrated systems such as microfluidic chips. The tweezer, consisting of a Fresnel Zone Plate microfabricated on a glass slide, has the ability to trap particles without the need for high performance objective lenses.
The device was designed, fabricated, and tested by postdoctoral fellow Ethan Schonbrun and undergraduate researcher Charles Rinzler under the direction of Assistant Professor of Electrical Engineering Ken Crozier (all are affiliated with SEAS). The team's results were published in the February 18th edition of Applied Physics Letters and the researchers have filed a U.S. provisional patent covering this new device.
"The microfabricated nature of the new optical tweezer offers an important advantage over conventional optical tweezers based on microscope objective lenses," says Crozier. "High performance objective lenses usually have very short working distances -- the trap is often ~200 mm or less from the front surface of the lens. This prevents their use in many microfluidic chips since these frequently have glass walls that are thicker than this."
The researchers note that the Fresnel Zone Plate optical tweezers could be fabricated on the inner walls of microfluidic channels or even inside cylindrical or spherical chambers and could perform calibrated force measurements in a footprint of only 100x100Î¼m.
Traditional tweezers, by contrast, would suffer from crippling aberrations in such locations. Moreover, in experimental trials, the optical tweezers exhibited trapping performance comparable to conventional optical tweezers when the diffraction efficiency was taken into account.
The researchers envision using their new tweezer inside microfluidic chips to carry out fluid velocity, refractive index, and local viscosity measurements. Additional applications include biological force measurements and sorting particles based on their size and refractive index. Particle-sorting chips based on large arrays of tweezers could be used to extract the components of interest of a biological sample in a high-throughput manner.
Michael Patrick Rutter | EurekAlert!
What happens when we heat the atomic lattice of a magnet all of a sudden?
18.07.2018 | Forschungsverbund Berlin
Subaru Telescope helps pinpoint origin of ultra-high energy neutrino
16.07.2018 | National Institutes of Natural Sciences
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
19.07.2018 | Earth Sciences
19.07.2018 | Power and Electrical Engineering
19.07.2018 | Materials Sciences